Hmm I'd say it depends on the application! 4/4 signature could be used in a lot of genres, moods, and arrangements — same for 3/4 & 6/8. However, one could make the argument that 3/4 & 6/8 are creatively limiting seeing as many tunes in 3/4 & 6/8 are typically waltzes which, in their favor, can be expressive but could severely limit your stylistic choices. Me however I think all time signatures are neat :]
Couplex
3/4 is found mainly in orchestral music, BUT. Many musicians use this time signature when writing "fast" music because it is very good at helping you focus on the speed of the music. There are many examples in game music.
MsFluent
Oh I see...